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pulmonary vascular cells, such as pulmonary artery endothelial cells
(PAECs) and pulmonary artery smooth muscle cells (PASMCs), which in turn
causes neointima formation in the small pulmonary arteries.3 Although
rare, occurring at only 2.4 cases per million per year, PAH is a
progressive disease leading to an incident mortality rate of 15 within 1
year of diagnosis. Moreover, the mortality rate of PAH was reported in
2012, to be 51 within 7 years of diagnosis.4, 5PAH is a complex disease
with multiple etiologies and may be mediated by the interplay of genetic
background, epigenetic changes and pathobiological environmental
factors, which explains the great variability in susceptibility6 (Figure
1). Therefore, the defining molecular mechanisms involved in the
pathogenesis of PAH may arise from various aspects due to the multiple
etiologies and disease heterogeneity.
It's a nice place to take photos of the more luxurious vehicles I'm
testing. The main road meanders in a curving, lazy loop. I often look at
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are driving these days: a fair number of Range Rovers and Escalades, S
Class Benzes and other full sized European sedans, with the occasional
Lexus thrown in..
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